Marcel Bach Pages

Group Leader

Professor Gail Preston

Research area

Molecular Plant-Microbe Interactions; RNA biology

Research Description

I focus on the study of RNA-binding proteins (RBPs) in plants, with the aim to understand the repertoire of RBPs involved in in plant immunity and their role in plant defence responses against pathogens.

RNA-Binding Proteins have emerged as master regulators of gene expression and are essential for cellular RNA homeostasis. Upon pathogen attack, the transcriptome and proteome of plants changes dramatically as plant defences are induced and some RBPs have been shown to be important players orchestrating these changes. We aim to dissect, in a comprehensive manner, the role of RNA-binding proteins in plant immunity using the cutting-edge technique ‘RNA interactome capture’.

Publications

 

Bach-Pages, M., Homma, F., Kourelis, J., Kaschani, F., Mohammed, S., Kaiser, M., Hoorn, R.A.L.; Castello, A., Preston, G.M. (2020). Discovering the RNA-Binding Proteome of Plant Leaves with an Improved RNA Interactome Capture Method. Biomolecules, 10(4), 661. https://doi.org/10.3390/biom10040661

Campos-Soriano, L, Bundo M, Bach-Pages M, Chiang SF, Chiou TJ, San Segundo B (2020). Phosphate excess increases susceptibility to pathogen infection in rice. Molecular Plant Pathology, 21(4):555-570. https://doi.org/10.1111/mpp.12916

Garcia-Moreno M, Noerenberg M, Ni S, Jarvelin AI Gonzalez-Almela E, Lenz CE, Bach-Pages M, Cox V, Avolio R, Davis T, Hester S, Sohier TJM, Li B, Heikel G, Michlewski G, Sanz MA, Carrasco L, Ricci EP, Pelechano V, Davis I, Fischer B, Mohammed S, Castello A (2019). System-wide Profiling of RNA-Binding Proteins Uncovers Key Regulators of Virus Infection. Molecular Cell, https://doi.org/10.1016/j.molcel.2019.01.017

Bach-Pages M, and Preston GM (2018). Methods to Quantify Biotic-Induced Stress in Plants. Methods Mol Biol., 1734:241-255. http://doi.org/10.1007/978-1-4939-7604-1_19

Bach-Pages M, Castello A, and Preston GM (2017). Plant RNA Interactome Capture: Revealing the Plant RBPome. Trends in Plant Science, 22: 449-451. http://doi.org/10.1016/j.tplants.2017.04.006

Misas-Villamil JC, van der Burgh AM, Grosse-Holz F, Bach-Pages M, Kovács J, Kaschani F, Schilasky S, Emon AE, Ruben M, Kaiser M, Overkleeft HS, van der Hoorn RA. (2017). Subunit-selective proteasome activity profiling uncovers uncoupled proteasome subunit activities during bacterial infections. The Plant Journal, 90:418-430. http://doi.org/10.1111/tpj.13494