Professor Gail Preston
Molecular Plant-Microbe Interactions; RNA biology
I focus on the study of RNA-binding proteins (RBPs) in plants, with the aim to understand the repertoire of RBPs involved in in plant immunity and their role in plant defence responses against pathogens.
RNA-Binding Proteins have emerged as master regulators of gene expression and are essential for cellular RNA homeostasis. Upon pathogen attack, the transcriptome and proteome of plants changes dramatically as plant defences are induced and some RBPs have been shown to be important players orchestrating these changes. We aim to dissect, in a comprehensive manner, the role of RNA-binding proteins in plant immunity using the cutting-edge technique ‘RNA interactome capture’.
Garcia-Moreno M, Noerenberg M, Ni S, Jarvelin AI Gonzalez-Almela E, Lenz CE, Bach-Pages M, Cox V, Avolio R, Davis T, Hester S, Sohier TJM, Li B, Heikel G, Michlewski G, Sanz MA, Carrasco L, Ricci EP, Pelechano V, Davis I, Fischer B, Mohammed S, Castello A (2019). System-wide Profiling of RNA-Binding Proteins Uncovers Key Regulators of Virus Infection. Molecular Cell, https://doi.org/10.1016/j.molcel.2019.01.017
Bach-Pages M, and Preston GM (2018). Methods to Quantify Biotic-Induced Stress in Plants. Methods Mol Biol., 1734:241-255.
Bach-Pages M, Castello A, and Preston GM (2017). Plant RNA Interactome Capture: Revealing the Plant RBPome. Trends in Plant Science, 22: 449-451
Misas-Villamil JC, van der Burgh AM, Grosse-Holz F, Bach-Pages M, Kovács J, Kaschani F, Schilasky S, Emon AE, Ruben M, Kaiser M, Overkleeft HS, van der Hoorn RA. (2017). Subunit-selective proteasome activity profiling uncovers uncoupled proteasome subunit activities during bacterial infections. The Plant Journal, 90:418-430