Dr Charlotte Kirchhelle

Research Interests

From edge to organ: the role of cell geometry in plant morphogenesis.

How do organisms develop the diverse anatomical shapes observed in nature? Answering this question is pivotal for our basic understanding of multicellular organisms and the rational improvement of domesticated species. However, the underlying process of morphogenesis is highly complex: it involves integrating different kinds of information (genetic, biochemical, biomechanical, and geometric) across multiple scales in space and time. Since this complexity poses a significant challenge to traditional experimental approaches, I will adopt an interdisciplinary approach combining classic molecular biology with state-of-the-art quantitative imaging and computational modelling to study plant morphogenesis, focussing on the recently identified role of cell geometric edges.

Publications
  • The importance of being edgy: cell geometric edges as an emerging polar domain in plant cells.

  • Optimizing Rhizobium-legume symbioses by simultaneous measurement of rhizobial competitiveness and N2 fixation in nodules.

  • Spatio-temporal control of post-Golgi exocytic trafficking in plants.

  • The Formation of a Camalexin Biosynthetic Metabolon.

  • Two mechanisms regulate directional cell growth in Arabidopsis lateral roots.

  • Universal Methods for Transgene Induction Using the Dexamethasone-Inducible Transcription Activation System pOp6/LhGR in Arabidopsis and Other Plant Species.

  • A Simple Chamber for Long-term Confocal Imaging of Root and Hypocotyl Development.

  • The Specification of Geometric Edges by a Plant Rab GTPase Is an Essential Cell-Patterning Principle During Organogenesis in Arabidopsis.

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