Dr Angela Hay Ph.D.
Royal Society University Research Fellow
Dr AS Hay
Research Area
Comparative plant development
Research Description
My research interests include developmental genetics and the evolution of developmental mechanisms. Evolution has produced marvelous variety in flowering plants, particularly in their floral structures. A key question in biology is how molecular changes in developmental pathways lead to changes in morphology during evolution. My research aims to identify the genetic differences that underlie divergence in floral structure between two closely related species, Arabidopsis thaliana and Cardamine hirsuta.
Hay Group Members
Publications (while at this department)
Bilsborough, GD, Runions, A, Barkoulas, M, Jenkins, HW, Hasson, A, Galinha, C, Laufs, P, Hay, A, Prusinkiewicz, P, Tsiantis, M. (2011) Model for the regulation of Arabidopsis thaliana leaf margin development PNAS. 108 (8): pp 3424-3429.
doi:10.1073/pnas.1015162108.
Hay, A, Tsiantis, M. (2010) KNOX genes: Versatile regulators of plant development and diversity Development. 137 (19): pp 3153-3165.
doi:10.1242/dev.030049.
McKim, S, Hay, A. (2010) Patterning and evolution of floral structures - marking time Current Opinion in Genetics and Development. 20 (4): pp 448-453.
doi:10.1016/j.gde.2010.04.007.
Piazza, P, Bailey, C.D, Cartolano, M, Krieger, J, Cao, J, Ossowski, S, Schneeberger, K, He, F, De, Meaux J, Hall, N, MacLeod, N, Filatov, D, Hay, A, Tsiantis, M. (2010) Arabidopsis thaliana leaf form evolved via loss of KNOX expression in leaves in association with a selective sweep Current Biology. 20 (24): pp 2223-2228.
doi:10.1016/j.cub.2010.11.037.
Barkoulas, M, Hay, A, Kougioumoutzi, E, Tsiantis, M. (2008) A developmental framework for dissected leaf formation in the Arabidopsis relative Cardamine hirsuta Nature Genetics..
doi:10.1038/ng.189.
Blein, T, Pulido, A, Vialette-Guiraud, A, Nikovics, K, Morin, H, Hay, A, Johansen, I.E, Tsiantis, M, Laufs, P. (2008) A conserved molecular framework for compound leaf development Science. 322 (5909): pp 1835-1839.
doi:10.1126/science.1166168.
Jasinski, S, Tattersall, A, Piazza, P, Hay, A, Martinez-Garcia, J.F, Schmitz, G, Theres, K, McCormick, S, Tsiantis, M. (2008) PROCERA encodes a DELLA protein that mediates control of dissected leaf form in tomato The Plant Journal. 56 (4): pp 603-612.
doi:10.1111/j.1365-313X.2008.03628.x.
Hay, A, Tsiantis, M. (2006) The genetic basis for differences in leaf form between Arabidopsis thaliana and its wild relative Cardamine hirsuta Nature Genetics. 38 (8): pp 942-947.
doi:10.1038/ng1835.
Hay, A, Barkoulas, M, Tsiantis, M. (2006) ASYMMETRIC LEAVES1 and auxin activities converge to repress BREVIPEDICELLUS expression and promote leaf development in Arabidopsis Development. 133 (20): pp 3955-3961.
doi:10.1242/dev.02545.
Grigg, S.P, Canales, C, Hay, A, Tsiantis, M. (2005) SERRATE coordinates shoot meristem function and leaf axial patterning in Arabidopsis Nature. 437 (7061): pp 1022-1026.
doi:10.1038/nature04052.
Hay, A, Tsiantis, M. (2005) From genes to plants via meristems Development. 132 (12): pp 2679-2684.
doi:10.1242/dev.01880.
Jasinski, S, Piazza, P, Craft, J, Hay, A, Woolley, L, Rieu, I, Phillips, A, Hedden, P, Tsiantis, M. (2005) KNOX action in Arabidopsis is mediated by coordinate regulation of cytokinin and gibberellin activities Current Biology. 15 (17): pp 1560-1565.
doi:10.1016/j.cub.2005.07.023.
Foster, T, Hay, A, Johnston, R, Hake, S. (2004) The establishment of axial patterning in the maize leaf Development. 131 (16): pp 3921-3929.
doi:10.1242/dev.01262.
Hay, A, Hake, S. (2004) The dominant mutant Wavy auricle in blade1 disrupts patterning in a lateral domain of the maize leaf Plant Physiology. 135 (1): pp 300-308
Hay, A, Craft, J, Tsiantis, M. (2004) Plant hormones and homeoboxes: Bridging the gap? BioEssays. 26 (4): pp 395-404
Hay, A, Barkoulas, M, Tsiantis, M. (2004) PINning down the connections: Transcription factors and hormones in leaf morphogenesis Current Opinion in Plant Biology. 7 (5): pp 575-581.
doi:10.1016/j.pbi.2004.07.007.
Hay, A, Jackson, D, Ori, N, Hake, S. (2003) Analysis of the Competence to Respond to KNOTTED1 Activity in Arabidopsis Leaves Using a Steroid Induction System Plant Physiology. 131: pp 1671-1680.
doi:10.1104/pp.102.017434.
Tsiantis, M, Hay, A. (2003) Comparative plant development: The time of the leaf? Nature Reviews Genetics. 4 (3): pp 169-180.
doi:10.1038/nrg1002.
Hay, A, Kaur, H, Phillips, A, Hedden, P, Hake, S, Tsiantis, M. (2002) The gibberellin pathway mediates KNOTTED1-type homeobox function in plants with different body plans Current Biology. 12 (18): pp 1557-1565.
doi:10.1016/S0960-9822(02)01125-9.