Dr Haruko Okamoto
IWATE Medical School, School of Pharmacy
Dr H Okamoto
Signal transduction, photobiology
Our main interest is to dissect the molecular basis of heterotrimeric G-protein signalling in processes modulated by light. The genome of the model plant Arabidopsis encodes just one gene of each of the G alpha and G beta subunits thus providing us with a uniquely simple system. T-DNA insertion mutants as well as plants overexpressing G alpha and G beta subunit have been analyzed for their physiological characteristics in response to a range of environmental signals. Our main focus is to understand the molecular basis of heterotrimeric G-protein signalling in Arabidopsis by employing techniques of molecular biology, cell biology and genetics. Light signalling pathways, mediated by a range of photoreceptors such as cryptochromes and phytochromes, have been identified as one of the many pathways in which heterotrimeric G-proteins function and therefore we are using light signals as a primary input to understand the G-protein signalling process.
Publications (while at this department)
2010) Jasmonate and phytochrome a signaling in arabidopsis wound and shade responses are integrated through JAZ1 stability Plant Cell. 22 (4): pp 1143-1160.
2009) Effect of magnetic fields on cryptochrome-dependent responses in Arabidopsis thaliana Journal of the Royal Society Interface. 6 (41): pp 1193-1205.
2009) The Î±-subunit of the heterotrimeric G-protein affects jasmonate responses in Arabidopsis thaliana Journal of Experimental Botany. 60 (7): pp 1991-2003.
2004) Abscisic acid induces CBF gene transcription and subsequent induction of cold-regulated genes via the CRT promoter element Plant Physiology. 135 (3): pp 1710-1717
2004) OXI1 kinase is necessary for oxidative burst-mediated signalling in Arabidopsis Nature. 427 (6977): pp 858-861
2003) Molecular Cloning and Functional Analysis of a Novel Type of Bowman-Birk Inhibitor Gene Family in Rice Plant Physiology. 133 (2): pp 560-570
2002) Biochemical evidence for ubiquitin ligase activity of the Arabidopsis COP1 interacting protein 8 (CIP8) Plant Journal. 30 (4): pp 385-394.
Professor Peter J. Hore
Dr. Christiane R. Timmel
Dr. Margaret Ahmad
Professor John G. Turner
Dr. Fran Robson