Dr DA Filatov

Research Area

Population genetics and molecular evolution

Research Description

Software (ProSeq) page

My research interests are connected with experimental molecular population genetics and evolution. In particular, I am interested in evolution of sex chromosomes, mating systems, molecular adaptation and in speciation process. We use dioecious Silene latifolia to study sex chromosome evolution, population genetics of speciation and quantitative genetics of sexual dimorphism. Evolution of fungal 'sex chromosomes' is conducted in a parasitic genus Microbotryum, which is a parasite of various Silene species. We also have several projects devoted to plant adaptation to contrasting environments and speciation process. These projects are conducted in Senecio (mainly altitudinal gradient on Mt Etna), endemic Hawaiian plant genus Schiedea (Caryophyllaceae), that undergone recent ‘explosive’ adaptive radiation, and rapid recent radiation of New World Lupins. Recently we also started a project to analyse sex chromosome evolution in annual mercuries (Mercurialis annua).

Filatov Group Members

Postdoctoral Researchers
Dr Mark Chapman
Dr Xin-Sheng Hu
Dr Maxim Kapralov
Dr Mamadou Mboup

Graduate Students
Mr Owen Osborne

Visiting Researchers
Dr Li Li

Publications (while at this department)

Kapralov, M.V, Votintseva, A.A, Filatov, D.A. (2013) Molecular adaptation during a rapid adaptive radiation Molecular Biology and Evolution. 30 (5): pp 1051-1059.
doi:10.1093/molbev/mst013.

Kapralov, M.V, Smith, J.A.C, Filatov, D.A. (2012) Rubisco Evolution in C4 Eudicots: An Analysis of Amaranthaceae Sensu Lato PLoS ONE. 7 (12):.
doi:10.1371/journal.pone.0052974.

Muir, G, Dixon, C.J, Harper, A.L, Filatov, D.A. (2012) Dynamics of drift, gene flow, and selection during speciation in silene Evolution..
doi:10.1111/j.1558-5646.2011.01529.x.

Young, J.N, Rickaby, R.E.M, Kapralov, M.V, Filatov, D.A. (2012) Adaptive signals in algal Rubisco reveal a history of ancient atmospheric carbon dioxide Philosophical Transactions of the Royal Society B: Biological Sciences. 367 (1588): pp 483-492.
doi:10.1098/rstb.2011.0145.

Chibalina, M.V, Filatov, D.A. (2011) Plant Y Chromosome Degeneration Is Retarded by Haploid Purifying Selection Current Biology. 21 (17): pp 1475-1479.
doi:10.1016/j.cub.2011.07.045.

Dixon, C.J, Kapralov, M.V, Filatov, D.A. (2011) Gene flow and species cohesion following the spread of Schiedea globosa (Caryophyllaceae) across the Hawaiian Islands Journal of Evolutionary Biology. 24 (1): pp 1-11.
doi:10.1111/j.1420-9101.2010.02128.x.

Howell, E.C, Armstrong, S.J, Filatov, D.A. (2011) Dynamic gene order on the Silene latifolia Y chromosome Chromosoma. pp 1-10.
doi:10.1007/s00412-011-0311-3.

Kapralov, M.V, Kubien, D.S, Andersson, I, Filatov, D.A. (2011) Changes in Rubisco kinetics during the evolution of C4 Photosynthesis in Flaveria (Asteraceae) are associated with positive selection on genes encoding the enzyme Molecular Biology and Evolution. 28 (4): pp 1491-1503.
doi:10.1093/molbev/msq335.

Muir, G, Bergero, R, Charlesworth, D, Filatov, D.A. (2011) DOES LOCAL ADAPTATION CAUSE HIGH POPULATION DIFFERENTIATION OF SILENE LATIFOLIA Y CHROMOSOMES? Evolution..
doi:10.1111/j.1558-5646.2011.01410.x.

Votintseva, A.A, Filatov, D.A. (2011) DNA polymorphism in recombining and non-recombing mating-type-specific loci of the smut fungus Microbotryum Heredity. 106 (6): pp 936-944.
doi:10.1038/hdy.2010.140.

Gossmann, T.I, Song, B.-H, Windsor, A.J, Mitchell-Olds, T, Dixon, C.J, Kapralov, M.V, Filatov, D.A, Eyre-Walker, A. (2010) Genome wide analyses reveal little evidence for adaptive evolution in many plant species Molecular Biology and Evolution. 27 (8): pp 1822-1832.
doi:10.1093/molbev/msq079.

Piazza, P, Bailey, C.D, Cartolano, M, Krieger, J, Cao, J, Ossowski, S, Schneeberger, K, He, F, De, Meaux J, Hall, N, MacLeod, N, Filatov, D, Hay, A, Tsiantis, M. (2010) Arabidopsis thaliana leaf form evolved via loss of KNOX expression in leaves in association with a selective sweep Current Biology. 20 (24): pp 2223-2228.
doi:10.1016/j.cub.2010.11.037.

Ridout, K.E, Dixon, C.J, Filatov, D.A. (2010) Positive selection differs between protein secondary structure elements in Drosophila Genome Biology and Evolution. 2 (1): pp 166-179.
doi:10.1093/gbe/evq008.

Bernasconi, G, Antonovics, J, Biere, A, Charlesworth, D, Delph, L.F, Filatov, D, Giraud, T, Hood, M.E, Marais, G.A.B, McCauley, D, Pannell, J.R, Shykoff, J.A, Vyskot, B, Wolfe, L.M, Widmer, A. (2009) Silene as a model system in ecology and evolution Heredity. 103 (1): pp 5-14.
doi:10.1038/hdy.2009.34.

Filatov, D.A. (2009) Processing and population genetic analysis of multigenic datasets with ProSeq3 software Bioinformatics. 25 (23): pp 3189-3190.
doi:10.1093/bioinformatics/btp572.

Filatov, D.A, Howell, E.C, Groutides, C, Armstrong, S.J. (2009) Recent spread of a retrotransposon in the Silene latifolia genome, apart from the Y chromosome Genetics. 181 (2): pp 811-817.
doi:10.1534/genetics.108.099267.

Floyd, N, Oldham, N.J, Eyles, C.J, Taylor, S, Filatov, D.A, Brouard, M, Davis, B.G. (2009) Photoinduced, family-specific, site-selective cleavage of TIM-barrel proteins Journal of the American Chemical Society. 131 (35): pp 12518-12519.
doi:10.1021/ja9026105.

Howell, E.C, Armstrong, S.J, Filatov, D.A. (2009) Evolution of neo-sex chromosomes in Silene diclinis Genetics. 182 (4): pp 1109-1115.
doi:10.1534/genetics.109.103580.

Kapralov, M.V, Stift, M, Filatov, D.A. (2009) Evolution of Genome size in Hawaiian Endemic Genus Schiedea (Caryophyllaceae) Tropical Plant Biology. 2 (2): pp 77-83.
doi:10.1007/s12042-009-9029-2.

Votintseva, AA, Filatov, DA. (2009) Evolutionary strata in a small mating-type-specific region of the smut fungus Microbotryum violaceum Genetics. 182 (4): pp 1391-1396.
doi:10.1534/genetics.109.103192.

Armstrong, S.J, Filatov, D.A. (2008) A cytogenetic view of sex chromosome evolution in plants Cytogenetic and Genome Research. 120: pp 241-246.
doi:10.1159/000121073.

Filatov, D.A. (2008) A selective sweep in or near the Silence latifolia X-linked gene SlssX Genetics Research. 90 (1): pp 85-95.
doi:10.1017/S0016672307009056.

Muir, G, Filatov, D. (2007) A selective sweep in the chloroplast DNA of dioecious silene (Section Elisanthe) Genetics. 177 (2): pp 1239-1239.
doi:10.1534/genetics.107.071969.

Funding

BBSRC, NERC, Leverhulme Trust

Collaborators

My group collaborates with Profs. Simon Hiscock (Bristol) and Richard Abbott (St Andrews) to study genetic bases of speciation and adaptation in Senecio.

We also collaborate with Dr Colin Hughes (Zurich) on the Lupin speciation project.

Evolution of sex chromosomes in Silene project gradually developed since the time I was a postdoc in Prof Deborah Charlesworth lab (Edinburgh) and I keep collaborating with Deborah on this project.

An emerging project devoted to sex chromosome evolution in Mercurialis is developed jointly with Prof. John Pannell (University of Lausanne).

Evolution of photosynthesis (C3/C4) project is in collaboration with Prof Andrew Smith (Plant Sci, Oxford) and Dr Ros Rickaby (Earth Sci, Oxford).

Patterns of DNA polymorphism and divergence in Arabidopsis and its relative Cardamine hirsuta are studies in collaboration with Prof. Miltos Tsiantis and Dr. Angela Hay (Plant Sci, Oxford).