Professor Lee Sweetlove

Professor of Plant Sciences

Tel +44 (0) 1865 275000

Research Area

Rational engineering of plant metabolic networks.

Research Description

The growth of plants is underpinned by, and in many cases limited by, the capacity of their metabolic systems. In green tissues, the process of photosynthesis transduces light energy into chemical energy to power the assimilation of carbon and nitrogen from the environment, the biosynthesis and maintenance of cellular components and export of sugars and amino acids to support the growth of the rest of plant. There is renewed interest in these metabolic processes due to concerns about the productivity of the global agricultural system in relation to an ever-increasing demand for food.

The research in my lab aims to develop a better understanding of the behaviour of the metabolic systems of plants in order to devise metabolic engineering strategies that will improve the productivity and quality of crop plants. We use both computational and experimental approaches to achieve this.

Computational: we construct and analyse flux-balance models of large-scale (up to genome-scale) plant metabolic networks. We have spent the last few years refining the approach such that we are confident that these minimally-constrained models provide a realistic simulation of plant metabolism in leaves and non-photosynthetic tissues. The goal now is to exploit these models to design more efficient metabolic systems. We are particularly interested in using this approach to predict how the rice metabolic network needs to be modified to accommodate more efficient photosynthetic modes such as C4 photosynthesis and CAM.

Experimental: we are seeking to better understand and exploit two phenomena for metabolic engineering. The first is metabolite signalling which the plant uses to monitor its internal metabolic status. Many such signalling pathways are used as feedback loops which, if were removed, would release the brakes on anabolic metabolism and growth. We are characterising two metabolite signalling pathways: amino acid signalling (for N assimilation) and mitochondrial redox stress signalling (for stress metabolism) and are creating synthetic metabolite-responsive gene switches and sensors. The second phenomenon is metabolite channelling – the direct passage of metabolites between sequential enzymes in metabolic pathways. We have discovered that key pathways in plants can be dynamically assembled into systems in which metabolite channelling occurs and we are trying to understand the nature of these assemblies. This knowledge would be massively important for synthetic biology because it would allow the assembly of highly efficient metabolic modules that have minimal impact with the metabolism of the host organism.

All of these research programmes are funnelled into applied metabolic engineering. Currently I lead a multinational consortium project attempting to make wholesale genetic changes of both source and sink metabolism in tomato with the goal of dramatically increasing fruit yield.

I am currently seeking DPhil students to work on:

  • computational modelling of crop metabolic networks for enhanced productivity
  • dissection of metabolite signalling pathways
  • the metabolic cost of abiotic stress

Publications (while at this department)

Cheung, C.Y.M., Ratcliffe, R.G. and Sweetlove, L.J. (2015) A method of accounting for enzyme costs in flux balance analysis reveals alternative pathways and metabolite stores in an illuminated Arabidopsis leaf. Plant Physiol 169: 1671–1682

Snowden, C.J, Thomas, B, Baxter, C.J, Smith, J.A.C, Sweetlove, L.J. (2015) A tonoplast Glu/Asp/GABA exchanger that affects tomato fruit amino acid composition Plant Journal. 81 (5): pp 651-660. doi:10.1111/tpj.12766

Gehl, B, Lee, C.P, Bota, P, Blatt, M.R, Sweetlove, L.J. (2014) An arabidopsis stomatin-like protein affects mitochondrial respiratory supercomplex organization Plant Physiology. 164 (3): pp 1389-1400. doi:10.1104/pp.113.230383

Gehl, B, Sweetlove, L.J. (2014) Mitochondrial Band-7 family proteins: Scaffolds for respiratory chain assembly? Frontiers in Plant Science. 5:.
doi:10.3389/fpls.2014.00141

Masakapalli, S.K, Ritala, A, Dong, L, van, der Krol A.R, Oksman-Caldentey, K.-M, Ratcliffe, R.G, Sweetlove, L.J. (2014) Metabolic flux phenotype of tobacco hairy roots engineered for increased geraniol production Phytochemistry. doi:10.1016/j.phytochem.2013.12.007

Maurice, Cheung C.Y, Poolman, M.G, Fell, D.A, George, Ratcliffe R, Sweetlove, L.J. (2014) A diel flux balance model captures interactions between light and dark metabolism during day-night cycles in C3 and crassulacean acid metabolism leaves Plant Physiology. 165 (2): pp 917-929. doi:10.1104/pp.113.234468

O'Leary, B, Preston, G.M, Sweetlove, L.J. (2014) Increased β-cyanoalanine nitrilase activity improves cyanide tolerance and assimilation in arabidopsis Molecular Plant. 7 (1): pp 231-243. doi:10.1093/mp/sst110

Cheung, C.Y.M, Williams, T.C.R, Poolman, M.G, Fell, D.A, Ratcliffe, R.G, Sweetlove, L.J. (2013) A method for accounting for maintenance costs in flux balance analysis improves the prediction of plant cell metabolic phenotypes under stress conditions Plant Journal..
doi:10.1111/tpj.12252

Finkemeier, I, Konig, A.-C, Heard, W, Nunes-Nesi, A, Pham, P.A, Leister, D, Fernie, A.R, Sweetlove, L.J. (2013) Transcriptomic analysis of the role of carboxylic acids in metabolite signaling in arabidopsis leaves Plant Physiology. 162 (1): pp 239-253. doi:10.1104/pp.113.214114

Morgan, M.J, Osorio, S, Gehl, B, Baxter, C.J, Kruger, N.J, George, Ratcliffe R, Fernie, A.R, Sweetlove, L.J. (2013) Metabolic engineering of tomato fruit organic acid content guided by biochemical analysis of an introgression line Plant Physiology. 161 (1): pp 397-407. doi:10.1104/pp.112.209619

Sweetlove, L.J, Obata, T, Fernie, A.R. (2013) Systems analysis of metabolic phenotypes: what have we learnt? Trends in Plant Science..
doi:10.1016/j.tplants.2013.09.005

Sweetlove, L.J, Williams, T.C.R, Cheung, C.Y.M, Ratcliffe, R.G. (2013) Modelling metabolic CO2 evolution - a fresh perspective on respiration Plant, Cell and Environment. doi:10.1111/pce.12105

Sweetlove, L.J, Fernie, A.R. (2013) The spatial organization of metabolism within the plant cell Annual Review of Plant Biology. 64: pp 723-746.
doi:10.1146/annurev-arplant-050312-120233

Schwarzlander, M, Murphy, M.P, Duchen, M.R, Logan, D.C, Fricker, M.D, Halestrap, A.P, Muller, F.L, Rizutto, R, Dick, T.P, Meyer, A.J, Sweetlove, L.J. (2012) Mitochondrial 'flashes': a radical concept repHined Trends in Cell Biology. doi:10.1016/j.tcb.2012.07.007

Schwarzlander, M, Logan, D.C, Johnston, I.G, Jones, N.S, Meyer, A.J, Fricker, M.D, Sweetlove, L.J. (2012) Pulsing of membrane potential in individual mitochondria: A stress-induced mechanism to regulate respiratory bioenergetics in Arabidopsis Plant Cell. 24 (3): pp 1188-1201. doi:10.1105/tpc.112.096438

Schwarzlander, M, Konig, A.-C, Sweetlove, L.J, Finkemeier, I. (2012) The impact of impaired mitochondrial function on retrograde signalling: A meta-analysis of transcriptomic responses Journal of Experimental Botany. 63 (4): pp 1735-1750. doi:10.1093/jxb/err374

Wirtz, M, Beard, K.F.M, Lee, C.P, Boltz, A, Schwarzlander, M, Fuchs, C, Meyer, A.J, Heeg, C, Sweetlove, L.J, Ratcliffe, R.G, Hell, R. (2012) Mitochondrial cysteine synthase complex regulates O-acetylserine biosynthesis in plants Journal of Biological Chemistry. 287 (33): pp 27941-27947. doi:10.1074/jbc.M112.372656

Araujo, W.L, Nunes-Nesi, A, Nikoloski, Z, Sweetlove, L.J, Fernie, A.R. (2011) Metabolic control and regulation of the tricarboxylic acid cycle in photosynthetic and heterotrophic plant tissues Plant, Cell and Environment. doi:10.1111/j.1365-3040.2011.02332.x

Finkemeier, I, Laxa, M, Miguet, L, Howden, A.J.M, Sweetlove, L.J. (2011) Proteins of diverse function and subcellular location are lysine acetylated in Arabidopsis Plant Physiology. 155 (4): pp 1779-1790. doi:10.1104/pp.110.171595

Howden, A.J, Salek, M, Miguet, L, Pullen, M, Thomas, B, Knight, M.R, Sweetlove, L.J. (2011) The phosphoproteome of Arabidopsis plants lacking the oxidative signal-inducible1 (OXI1) protein kinase New Phytologist. 190 (1): pp 49-56. doi:10.1111/j.1469-8137.2010.03582.x

Lehmann, M, Laxa, M, Sweetlove, L.J, Fernie, A.R, Obata, T. (2011) Metabolic recovery of Arabidopsis thaliana roots following cessation of oxidative stress Metabolomics. pp 1-11. doi:10.1007/s11306-011-0296-1

Obata, T, Matthes, A, Koszior, S, Lehmann, M, Araujo, W.L, Bock, R, Sweetlove, L.J, Fernie, A.R. (2011) Alteration of mitochondrial protein complexes in relation to metabolic regulation under short-term oxidative stress in Arabidopsis seedlings Phytochemistry. 72 (10): pp 1081-1091. doi:10.1016/j.phytochem.2010.11.003

Schwarzlander, M, Logan, D.C, Fricker, M.D, Sweetlove, L.J. (2011) The circularly permuted yellow fluorescent protein cpYFP that has been used as a superoxide probe is highly responsive to pH but not superoxide in mitochondria: Implications for the existence of superoxide 'flashes' Biochemical Journal. 437 (3): pp 381-387. doi:10.1042/BJ20110883

Williams, T.C.R, Sweetlove, L.J, George, Ratcliffe R. (2011) Capturing metabolite channeling in metabolic flux phenotypes Plant Physiology. 157 (3): pp 981-984.
doi:10.1104/pp.111.184887

Moller, I.M, Sweetlove, L.J. (2010) ROS signalling - specificity is required Trends in Plant Science. 15 (7): pp 370-374. doi:10.1016/j.tplants.2010.04.008

Sweetlove, L.J, Beard, K.F.M, Nunes-Nesi, A, Fernie, A.R, Ratcliffe, R.G. (2010) Not just a circle: flux modes in the plant TCA cycle Trends in Plant Science. doi:10.1016/j.tplants.2010.05.006

Williams, T.C.R, Poolman, M.G, Howden, A.J.M, Schwarzlander, M, Fell, D.A, Ratcliffe, R.G, Sweetlove, L.J. (2010) A Genome-scale metabolic model accurately predicts fluxes in central carbon metabolism under stress conditions Plant Physiology. 154 (1): pp 311-323. doi:10.1104/pp.110.158535

Lehmann, M, Schwarzländer, M, Obata, T, Sirikantaramas, S, Burow, M, Olsen, CE, Tohge, T, Fricker, MD, Møller, BL, Fernie, AR, Sweetlove, LJ, Laxa, M. (2009) The metabolic response of arabidopsis roots to oxidative stress is distinct from that of heterotrophic cells in culture and highlights a complex relationship between the levels of transcripts, metabolites, and flux Molecular Plant. 2 (3): pp 390-406. doi:10.1093/mp/ssn080

Marty, L, Siala, W, Schwarzlander, M, Fricker, M.D, Wirtz, M, Sweetlove, L.J, Meyer, Y, Meyer, A.J, Reichheld, J.-P, Hell, R. (2009) The NADPH-dependent thioredoxin system constitutes a functional backup for cytosolic glutathione reductase in Arabidopsis Proceedings of the National Academy of Sciences of the United States of America. 106 (22): pp 9109-9114. doi:10.1073/pnas.0900206106

Poolman, M.G, Miguet, L, Sweetlove, L.J, Fell, D.A. (2009) A genome-scale metabolic model of Arabidopsis and some of its properties Plant Physiology. 151 (3): pp 1570-1581. doi:10.1104/pp.109.141267

Rigas, S, Daras, G, Laxa, M, Marathias, N, Fasseas, C, Sweetlove, L.J, Hatzopoulos, P. (2009) Role of Lon1 protease in post-germinative growth and maintenance of mitochondrial function in Arabidopsis thaliana New Phytologist. 181 (3): pp 588-600. doi:10.1111/j.1469-8137.2008.02701.x

Rigas, S, Daras, G, Sweetlove, L.J, Hatzopoulos, P. (2009) Mitochondria biogenesis via Lon1 selective proteolysis: Who dares to live for ever? Plant Signaling and Behavior. 4 (3): pp 221-224. 

Schwarzlander, M, Fricker, M.D, Sweetlove, L.J. (2009) Monitoring the in vivo redox state of plant mitochondria: Effect of respiratory inhibitors, abiotic stress and assessment of recovery from oxidative challenge Biochimica et Biophysica Acta - Bioenergetics. 1787 (5): pp 468-475. doi:10.1016/j.bbabio.2009.01.020

Sweetlove, L.J, Moller, I.M. (2009) Chapter 1 Oxidation of Proteins in Plants-Mechanisms and Consequences Advances in Botanical Research. 52: pp 1-23. doi:10.1016/S0065-2296(10)52001-9

Morgan, M.J, Lehmann, M, Schwarzlander, M, Baxter, C.J, Sienkiewicz-Porzucek, A, Williams, T.C.R, Schauer, N, Fernie, A.R, Fricker, M.D, Ratcliffe, R.G, Sweetlove, L.J, Finkemeier, I. (2008) Decrease in manganese superoxide dismutase leads to reduced root growth and affects tricarboxylic acid cycle flux and mitochondrial redox homeostasis Plant Physiology. 147 (1): pp 101-114. doi:10.1104/pp.107.113613

Schwarzlander, M, Fricker, M.D, Muller, C, Marty, L, Brach, T, Novak, J, Sweetlove, L.J, Hell, R, Meyer, A.J. (2008) Confocal imaging of glutathione redox potential in living plant cells Journal of Microscopy. 231 (2): pp 299-316. doi:10.1111/j.1365-2818.2008.02030.x

Sweetlove, L.J, Fell, D, Fernie, A.R. (2008) Getting to grips with the plant metabolic network Biochemical Journal. 409 (1): pp 27-41. doi:10.1042/BJ20071115

Williams, T.C.R, Miguet, L, Masakapalli, S.K, Kruger, N.J, Sweetlove, L.J, Ratcliffe, R.G. (2008) Metabolic network fluxes in heterotrophic arabidopsis cells: Stability of the flux distribution under different oxygenation conditions Plant Physiology. 148 (2): pp 704-718. doi:10.1104/pp.108.125195

Baxter, C.J, Redestig, H, Schauer, N, Repsilber, D, Patil, K.R, Nielsen, J, Selbig, J, Liu, J, Fernie, A.R, Sweetlove, L.J. (2007) The metabolic response of heterotrophic Arabidopsis cells to oxidative stress Plant Physiology. 143 (1): pp 312-325. doi:10.1104/pp.106.090431

Baxter, C.J, Liu, J.L, Fernie, A.R, Sweetlove, L.J. (2007) Determination of metabolic fluxes in a non-steady-state system Phytochemistry. 68: pp 2313-2319. doi:10.1016/j.phytochem.2007.04.026

Graham, J.W.A, Williams, T.C.R, Morgan, M, Fernie, A.R, Ratcliffe, R.G, Sweetlove, L.J. (2007) Glycolytic enzymes associate dynamically with mitochondria in response to respiratory demand and support substrate channeling Plant Cell. 19 (11): pp 3723-3738. doi:10.1105/tpc.107.053371

Nunes-Nesi, A, Carrari, F, Gibon, Y, Sulpice, R, Lytovchenko, A, Fisahn, J, Graham, J, Ratcliffe, R.G, Sweetlove, L.J, Fernie, A.R. (2007) Deficiency of mitochondrial fumarase activity in tomato plants impairs photosynthesis via an effect on stomatal function Plant Journal. 50 (6): pp 1093-1106. doi:10.1111/j.1365-313X.2007.03115.x

Nunes-Nesi, A, Sweetlove, L.J, Fernie, A.R. (2007) Operation and function of the tricarboxylic acid cycle in the illuminated leaf Physiologia Plantarum. 129 (1): pp 45-56.
doi:10.1111/j.1399-3054.2006.00778.x

Sweetlove, L.J, Taylor, N.L, Leaver, C.J. (2007) Isolation of intact, functional mitochondria from the model plant Arabidopsis thaliana. Methods in molecular biology (Clifton, N.J.). 372: pp 125-136. 

Sweetlove, L.J, Fait, A, Nunes-Nesi, A, Williams, T, Fernie, A.R. (2007) The mitochondrion: An integration point of cellular metabolism and signalling Critical Reviews in Plant Sciences. 26 (1): pp 17-43. doi:10.1080/07352680601147919

Brandina, I, Graham, J, Lemaitre-Guillier, C, Entelis, N, Krasheninnikov, I, Sweetlove, L, Tarassov, I, Martin, R.P. (2006) Enolase takes part in a macromolecular complex associated to mitochondria in yeast Biochimica et Biophysica Acta - Bioenergetics. 1757: pp 1217-1228. doi:10.1016/j.bbabio.2006.07.001

Carrari, F, Baxter, C, Usadel, B, Urbanczyk-Wochniak, E, Zanor, M.-I, Nunes-Nesi, A, Nikiforova, V, Centero, D, Ratzka, A, Pauly, M, Sweetlove, L.J, Fernie, A.R. (2006) Integrated analysis of metabolite and transcript levels reveals the metabolic shifts that underlie tomato fruit development and highlight regulatory aspects of metabolic network behavior Plant Physiology. 142 (4): pp 1380-1396. doi:10.1104/pp.106.088534

Dixon, M.H, Hill, S.A, Jackson, M.B, Ratcliffe, R.G, Sweetlove, L.J. (2006) Physiological and metabolic adaptations of Potamogeton pectinatus L. tubers support rapid elongation of stem tissue in the absence of oxygen Plant and Cell Physiology. 47 (1): pp 128-140. doi:10.1093/pcp/pci229

Finkemeier, I, Sweetlove, L. (2006) Signalling in primary metabolism New Phytologist. 171 (3): pp 445-447. doi:10.1111/j.1469-8137.2006.01805.x

Sweetlove, L.J, Lytovchenko, A, Morgan, M, Nunes-Nesi, A, Taylor, N.L, Baxter, C.J, Eickmeier, I, Fernie, A.R. (2006) Mitochondrial uncoupling protein is required for efficient photosynthesis Proceedings of the National Academy of Sciences of the United States of America. 103 (51): pp 19587-19592. doi:10.1073/pnas.0607751103

Baxter, C.J, Carrari, F, Bauke, A, Overy, S, Hill, S.A, Quick, P.W, Fernie, A.R, Sweetlove, L.J. (2005) Fruit carbohydrate metabolism in an introgression line of tomato with increased fruit soluble solids Plant and Cell Physiology. 46 (3): pp 425-437. doi:10.1093/pcp/pci040

Baxter, C.J, Sabar, M, Quick, W.P, Sweetlove, L.J. (2005) Comparison of changes in fruit gene expression in tomato introgression lines provides evidence of genome-wide transcriptional changes and reveals links to mapped QTLs and described traits Journal of Experimental Botany. 56 (416): pp 1591-1604. doi:10.1093/jxb/eri154

Finkemeier, I, Goodman, M, Lamkemeyer, P, Kandlbinder, A, Sweetlove, L.J, Dietz, K.-J. (2005) The mitochondrial type II peroxiredoxin F is essential for redox homeostasis and root growth of Arabidopsis thaliana under stress Journal of Biological Chemistry. 280 (13): pp 12168-12180. doi:10.1074/jbc.M413189200.

Giege, P, Sweetlove, L.J, Cognat, V, Leaver, C.J. (2005) Coordination of nuclear and mitochondrial genome expression during mitochondrial biogenesis in Arabidopsis Plant Cell. 17 (5): pp 1497-1512. doi:10.1105/tpc.104.030254

Ingle, R.A, Smith, J.A.C, Sweetlove, L.J. (2005) Responses to nickel in the proteome of the hyperaccumulator plant Alyssum lesbiacum BioMetals. 18 (6): pp 627-641. doi:10.1007/s10534-005-2999-0

Nunes-Nesi, A, Carrari, F, Lytovchenko, A, Smith, A.M.O, Loureiro, M.E, Ratcliffe, R.G, Sweetlove, L.J, Fernie, A.R. (2005) Enhanced photosynthetic performance and growth as a consequence of decreasing mitochondrial malate dehydrogenase activity in transgenic tomato plants Plant Physiology. 137 (2): pp 611-622. doi:10.1104/pp.104.055566

Overy, S.A, Walker, H.J, Malone, S, Howard, T.P, Baxter, C.J, Sweetlove, L.J, Hill, S.A, Quick, W.P. (2005) Application of metabolite profiling to the identification of traits in a population of tomato introgression lines Journal of Experimental Botany. 56 (410): pp 287-296. doi:10.1093/jxb/eri070

Sweetlove, L.J, Fernie, A.R. (2005) Regulation of metabolic networks: Understanding metabolic complexity in the systems biology era New Phytologist. 168 (1): pp 9-24.
doi:10.1111/j.1469-8137.2005.01513.x

Urbanczyk-Wochniak, E, Baxter, C, Kolbe, A, Kopka, J, Sweetlove, L.J, Fernie, A.R. (2005) Profiling of diurnal patterns of metabolite and transcript abundance in potato (Solanum tuberosum) leaves Planta. 221 (6): pp 891-903. doi:10.1007/s00425-005-1483-y

Fernie, A.R, Carrari, F, Sweetlove, L.J. (2004) Respiratory metabolism: Glycolysis, the TCA cycle and mitochondrial electron transport Current Opinion in Plant Biology. 7 (3): pp 254-261. doi:10.1016/j.pbi.2004.03.007

Smith, A.M.O, Ratcliffe, R.G, Sweetlove, L.J. (2004) Activation and function of mitochondrial uncoupling protein in plants Journal of Biological Chemistry. 279 (50): pp 51944-51952. doi:10.1074/jbc.M408920200

Swidzinski, J.A, Leaver, C.J, Sweetlove, L.J. (2004) A proteomic analysis of plant programmed cell death Phytochemistry. 65 (12): pp 1829-1838. doi:10.1016/j.phytochem.2004.04.020

Considine, M.J, Goodman, M, Echtay, K.S, Laloi, M, Whelan, J, Brand, M.D, Sweetlove, L.J. (2003) Superoxide stimulates a proton leak in potato mitochondria that is related to the activity of uncoupling protein Journal of Biological Chemistry. 278 (25): pp 22298-22302. 

Giege, P, Sweetlove, L.J, Leaver, C.J. (2003) Identification of mitochondrial protein complexes in arabidopsis using two-dimensional blue-native polyacrylamide gel electrophoresis Plant Molecular Biology Reporter. 21 (2): pp 133-144. 

Giege, P, Heazlewood, J.L, Roessner-Tunali, U, Harvey, Millar A, Fernie, A.R, Leaver, C.J, Sweetlove, L.J. (2003) Enzymes of glycolysis are functionally associated with the mitochondrion in arabidopsis cells Plant Cell. 15 (9): pp 2140-2151. 

Sweetlove, L.J, Last, R.L, Fernie, A.R. (2003) Predictive metabolic engineering: A goal for systems biology Plant Physiology. 132 (2): pp 420-425. 

Lytovchenko, A, Sweetlove, L, Pauly, M, Fernie, A.R. (2002) The influence of cytosolic phosphoglucomutase on photosynthetic carbohydrate metabolism Planta. 215 (6): pp 1013-1021. doi:10.1007/s00425-002-0826-1

Sweetlove, L.J, Tomlinson, K.L, Hill, S.A. (2002) The effect of exogenous sugars on the control of flux by adenosine 5′-diphosphoglucose pyrophosphorylase in potato tuber discs Planta. 214 (5): pp 741-750. doi:10.1007/s004250100666

Sweetlove, L.J, Heazlewood, J.L, Herald, V, Holtzapffel, R, Day, D.A, Leaver, C.J, Millar, A.H. (2002) The impact of oxidative stress on Arabidopsis mitochondria Plant Journal. 32 (6): pp 891-904. Swidzinski, J.A, Sweetlove, L.J, Leaver, C.J. (2002) A custom microarray analysis of gene expression during programmed cell death in Arabidopsis thaliana Plant Journal. 30 (4): pp 431-446. doi:10.1046/j.1365-313X.2002.01301.x

Sweetlove, L.J, Kruger, N.J, Hill, S.A. (2001) Starch synthesis in transgenic potato tubers with increased 3-phosphoglyceric acid content as a consequence of increased 6-phosphofructokinase activity Planta. 213 (3): pp 478-482. doi:10.1007/s004250100544.

Sweetlove, L.J, Mowday, B, Hebestreit, H.F, Leaver, C.J, Millar, A.H. (2001) Nucleoside diphosphate kinase III is localized to the inter-membrane space in plant mitochondria FEBS Letters. 508 (2): pp 272-276. doi:10.1016/S0014-5793(01)03069-1

Sweetlove, L.J, Dunford, R, Ratcliffe, R.G, Kruger, N.J. (2000) Lactate metabolism in potato tubers deficient in lactate dehydrogenase activity Plant, Cell and Environment. 23 (8): pp 873-881. doi:10.1046/j.1365-3040.2000.00605.x

Sweetlove, L.J, Hill, S.A. (2000) Source metabolism dominates the control of source to sink carbon flux in tuberizing potato plants throughout the diurnal cycle and under a range of environmental conditions Plant, Cell and Environment. 23 (5): pp 523-529. doi:10.1046/j.1365-3040.2000.00567.x

Sweetlove, L.J, Muller-Rober, B, Willmitzer, L, Hill, S.A. (1999) The contribution of adenosine 5'-diphosphoglucose pyrophosphorylase to the control of starch synthesis in potato tubers Planta. 209 (3): pp 330-337. doi:10.1007/s004250050640

Sweetlove, L.J, Kossmann, J, Riesmeier, J.W, Trethewey, R.N, Hill, S.A. (1998) The control of source to sink carbon flux during tuber development in potato Plant Journal. 15 (5): pp 697-706. doi:10.1046/j.1365-313X.1998.00247.x

Sweetlove, L.J, Burrell, M.M, Ap, Rees T. (1996) Starch metabolism in tubers of transgenic potato (Solanum tuberosum) with increased ADPglucose pyrophosphorylase Biochemical Journal. 320 (2): pp 493-498. 

Sweetlove, L.J, Burrell, M.M, Ap, Rees T. (1996) Characterization of transgenic potato (Solanum tuberosum) tubers with increased ADPglucose pyrophosphorylase Biochemical Journal. 320 (2): pp 487-492.