Tel: +44 1865 275122 (office)
Tel: +44 1865 275811 (lab)
The Plant Chemetics Laboratory
Department of Plant Sciences
University of Oxford
South Parks Road
Oxford OX1 3RB
Molecular Plant Pathology.
During plant-pathogen interactions, the plant apoplast (i.e. the extracellular space) is a battlefield. Upon infection, plants secrete proteases into the apoplast, amongst other hydrolytic enzymes. In return, pathogens produce proteases inhibitors to manipulate their host, for instance by suppressing defence responses. My project involves studying the role of apoplastic immune proteases in the defence response of Nicotiana benthamiana to bacterial pathogens. In particular, I study the contribution of serine proteases to plant immunity and their interplay with apoplastic inhibitors.
Sueldo, D. J., Shimels, M., Spirindon, L., Caldararu, O., Petrescu, A., Joosten, J., Tameling, W. (2015). Random mutagenesis of the nucleotide-binding domain of NRC1, a down-stream signalling NB-LRR, identifies gain-of-function mutations in the nucleotide-binding pocket. New Phytologist, 208: 210-223.
Sueldo D., Ahmed A., Misas-Villamil J., Colby T., Tameling W. I. L., Joosten M. H. A. J., van der Hoorn R. A. L. (2014). Dynamic hydrolase activities precede hypersensitive tissue collapse in tomato seedlings. New Phytologist, 203: 913-925.
Sueldo, D. J.*, Foresi, N. P.*, Casalongué C. A., Lamattina, L., Laxalt, A. M. (2010). Phosphatidic acid formation is required for extracellular ATP-mediated nitric oxide production in suspension-cultured tomato cells. New Phytologist, 185:909-916. * Equal contribution